What is Sermorelin?
Sermorelin is recorded under CAS 86168-78-7 with the formula C149H246N44O42S, an average molecular weight of 3357.93, and the synonyms GRF(1-29) and GHRH analogue. Our dataset carries no residue listing, so the sequence is not written out here; the classification as the amino-terminal 1-29 span of growth hormone releasing factor comes from the synonym on file.
That truncation is the defining fact about the molecule. The full releasing hormone runs considerably longer, and the segment retained here is the portion the literature identifies as sufficient for receptor activation. The single sulfur atom in the formula is consistent with one methionine, which makes oxidation a consideration, and the size, above three kilodaltons, means aggregation and surface adsorption matter more than for the short peptides in this catalog.
In published work the compound acts as a GHRH receptor agonist on pituitary somatotroph preparations and in animal studies of pulsatile growth hormone release. It is often the comparator against which longer-acting analogues are measured, because its short plasma half-life produces a sharp, self-limiting secretory pulse. Cleavage near the amino terminus by dipeptidyl peptidase 4 is the recognised clearance route, and how far species differences in that enzyme shape the results is not settled.
Reconstitution & handling
Sterile or bacteriostatic water is the standard diluent. Larger peptides dissolve more slowly than short sequences, so add the water against the vial wall, let it stand and swirl gently at intervals rather than agitating the cake into solution. Avoid foaming, a real loss mechanism at this molecular size. Concentration is labelled mass over diluent volume, adjusted by net peptide content.
Storage & stability
The lyophilized cake is the stable presentation, sealed at -20 °C, desiccated and dark. Reconstituted material should sit at 2 to 8 °C in single-use aliquots, since a peptide of this size is sensitive to freeze-thaw, with aggregation rather than hydrolysis the usual result. Low-binding containers reduce adsorptive loss, and cold vials should equilibrate before opening so moisture does not reach the powder.
How it's tested
Reversed-phase HPLC at 214 and 220 nm gives the purity figure, with related-substance peaks from deamidation and methionine oxidation reported where they resolve. Identity is confirmed by mass spectrometry against the theoretical average mass of 3357.93, read from a deconvoluted multiply charged envelope. Net peptide content and water are reported separately, and a lot-matched certificate of analysis is available on request.